Most sets of twins born to the same mother
Who
Mrs. Vassilyeva
What
16 total number
Where
Russian Federation (Shuya)
The first wife (died ante 1770), of Feodor Vassilyev (b. 1707–c.1782), a peasant from Shuya, Russia, gave birth to 16 sets of twins.
Barbara Zulu of Barberton, South Africa bore 3 sets of girls and 3 mixed sets in seven years (1967–73).

Anna Steynvaait of Johannesburg, South Africa produced 2 sets within 10 months in 1960.