- Who
- Andy Pettitte
- What
- 92 people
- Where
- ()
- When
- 2009
The Major League Baseball (MLB) record for most runners picked off in a career by a pitcher is 92 by Andy Pettitte (USA) pitching for the New York Yankees (USA) and Houston Astros (USA) from 1995 to 2009. Pick-offs has been an official statistic since 1973.