Most home runs leading off a game
- Who
- Rickey Henley Henderson
- When
- 2003
The Major League Baseball (MLB) record for most home runs leading off a game is 81 by Rickey Henderson (USA) playing for the Oakland Athletics, New York Yankees, San Diego Padres, Anaheim Angels, New York Mets, Seattle Mariners, Boston Red Sox, Los Angeles Dodgers (all USA) and the Toronto Blue Jays (Canada), from 1979 to 2003.