Most wins in an NFL career as a starting quarterback
- Who
- Tom Brady
- What
- 251 total number
- Where
- Not Applicable
- When
- 2022
The most regular-season wins by a starting quarterback in an NFL career is 251 by Tom Brady (USA) while playing for the New England Patriots and Tampa Bay Buccaneers from 2000 to 2022.
Brady compiled a career record of 251–82.