Most home runs in a Major League Baseball season by a designated hitter
- Who
- Kyle Schwarber
- Where
- Not Applicable
- When
- 01 January 2025
The Major League Baseball (MLB) record for most home runs hit by a designated hitter in a season is 56 by Kyle Schwarber playing for the Philadelphia Phillies in 2025.
Kyle Schwarber finished the season one home run ahead of Shohei Ohtani of the Los Angeles Dodgers, who had held the previous record of 54 from 2024. Schwarber also hit four home runs in one game during the 2025 season.