- Who
- Tom Brady
- What
- 649 total number
- Where
- Not Applicable ()
- When
- 2022
The most touchdown passes in an NFL career is 649, and was achieved by Tom Brady (USA), playing for the New England Patriots and Tampa Bay Buccaneers from 2000 to 2022.
The most touchdown passes in an NFL career is 649, and was achieved by Tom Brady (USA), playing for the New England Patriots and Tampa Bay Buccaneers from 2000 to 2022.