Most home runs hit by a team in one inning of a Major League Baseball (MLB) game
- Who
- Houston Astros, New York Yankees, Washington Nationals, Milwaukee Brewers, Minnesota Twins, San Francisco Giants, Philadelphia Phillies, New York Giants
- What
- 5 total number
- Where
- Not Applicable
- When
- 17 May 2022
The Major League Baseball (MLB) record for most home runs hit in one inning is five, a feat accomplished eight times, most recently by Houston Astros batters Yordan Alvarez (Cuba), Kyle Tucker (USA), Jeremy Pena (Dominican Republic), Michael Brantley (USA), and Yuli Gurriel (Cuba) in the second inning of a 13–4 win over the Boston Red Sox at Fenway Park in Boston, Massachusetts, (USA), on 17 May 2022.
Previous teams to hit five homers in one inning were: New York Yankees, fourth inning, on 17 September 2020, Washington Nationals, third inning, on 27 July 2017, Milwaukee Brewers, fourth inning, on 22 April 2006, Minnesota Twins, seventh inning, on 9 June 1966, San Francisco Giants, ninth inning, on 23 August 1961, Philadelphia Phillies, eighth inning, on 2 June 1949, and the New York Giants, fourth inning, on 6 June 1939 (all USA).