Most NFL game losses by an American football coach
- Who
- Dan Reeves, Jeff Fisher
- What
- 165 total number
- Where
- Not Applicable
- When
- 2016
The most American football games lost as National Football League (NFL) coach is 165. This was achieved by Dan Reeves (USA) while coaching the Denver Broncos, New York Giants and Atlanta Falcons (all USA) from 1981 to 2003. The feat was later achieved by Jeff Fisher (USA) while coaching the Houston Oilers, Tennessee Titans, St. Louis Rams and Los Angeles Rams (all USA) from 1994 to 2016.