Most 400-yard passing games in an NFL career
- Who
- Drew Brees
- What
- 16 total number
- Where
- United States
- When
- 09 September 2018
The most 400-yard passing games in an NFL career is 16, achieved by Drew Brees (USA) playing for the San Diego Chargers and New Orleans Saints between 2001 and 2018.
Brees 16th 400-yard passing game came in a 40-48 loss against the Tampa Bay Buccaneers in game week 1 of the 2018 season.