Highest margin of victory in the football (soccer) MLS (Major League Soccer)
- Who
- Vancouver Whitecaps, Philadelphia Union , Atlanta United, New York Red Bulls , Chicago Fire , LA Galaxy
- What
- 7 total number
- Where
- Canada (Vancouver)
- When
- 14 September 2025
The highest margin of victory in Major League Soccer is 7 goals, achieved by the LA Galaxy against Dallas Burn on 4 June 1998; and equalled by Chicago Fire against Kansas City Wizards on 4 July 2001; New York Red Bulls against New York City FC on 21 May 2016, and LA Galaxy on 10 May 2025; Atlanta United FC against New England Revolution on 13 September 2017; Philadelphia Union against DC United on 8 July 2022; and Vancouver Whitecaps FC against Philadelphia Union on 13 September 2025.
Five of these six games ended 7–0; the LA Galaxy defeated Dallas Burn 8–1.