Longest-running animated sitcom (by episode count)
The Simpsons
662 total number
United States ()

Based on number of episodes, the longest-running animated sitcom is The Simpsons (FOX, USA), which had aired 662 episodes since its debut ("Simpsons Roasting on an Open Fire") on 17 December 1989 up to the close of its 30th season ("Crystal Blue-Haired Persuasion") on 12 May 2019. The 31st season had already been commissioned.

The famous dysfunctional family from Springfield started life as a series of animated shorts on variety show The Tracey Ullman Show (FOX, USA, 1987–90), first appearing on 17 April 1987. They proved so popular that they went on to get their own primetime series, which debuted on 17 December 1989.

The Simpsons has also picked up the most Emmy Awards for an animated series: 33 as of 18 September 2018.