Most players used by a team in a Major League Baseball season
- Who
- Chicago Cubs
- What
- 69 total number
- Where
- Not Applicable
- When
- 2021
The Chicago Cubs set a Major League Baseball (MLB) record by using 69 players in 2021. That broke the previous mark of 67 players used by the Seattle Mariners in 2019. The Mariners also used a record 42 pitchers in 2019.