Most walk-off home runs in a Major League Baseball career
- Jim Thome
- Not Applicable
A game-ending home run is a home run on the final pitch of the game that results in a victory for the home team. The Major League Baseball (MLB) record for most game-ending home runs in a career is 13 by Jim Thome (USA) while playing for the Cleveland Indians, Philadelphia Phillies, Chicago White Sox, Los Angeles Dodgers, Minnesota Twins, and Baltimore Orioles (all USA) since 1991.