The best-selling trading card game is Yu-Gi-Oh! by Konami Digital Entertainment Co., Ltd. (Japan), which has sold 25,175,567,833 cards globally since 1999 as of 31 March 2011.
Yu-Gi-Oh! is based on the comic books and animated TV series by artist Kazuki Takahashi (Japan).
Comments below may relate to previous holders of this record.