Most games lost by a pitcher in a Major League Baseball career
Who
Denton True "Cy" Young
What
316 total number
Where
United States ()
When
1911
The pitcher to lose the most games in a career is Denton True Cy Young (USA) playing for the Cleveland Spiders, St Louis Cardinals, Boston Red Sox, Cleveland Indians and Boston Braves with 316 from 1890–1911.